U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients

  • Ziqiong Wang Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China
  • Ying Xu Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China
  • Hang Liao Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China
  • Xiaoping Chen Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China
  • Sen He Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China
Keywords: Hypertrophic cardiomyopathy, mortality, serum uric acid, U-shaped association

Abstract

Background. No study has examined the effect of low serum uric acid (SUA) concentrations on mortality in hypertrophic cardiomyopathy (HCM) patients. The aim of the present study was to assess the relations between both low and high SUA concentrations and the risk of mortality across the full range of SUA concentrations in a retrospective cohort of HCM patients.

Methods. A total of 454 HCM patients were enrolled in the study, and SUA concentrations were measured at baseline. The primary and secondary endpoints were all-cause mortality and HCM-related mortality, respectively. The associations between SUA concentrations and endpoints were analysed.

Results. During a median follow-up of 3.8 years, there were 80 (17.6%) all-cause mortality events, and 52 of them (11.5%) were ascribed to HCM-related mortality. Patients with SUA concentrations of 250–350 µmol/L had the lowest all-cause mortality rate (11.8%) and HCM-related mortality rate (5.0%). Both low and high SUA concentrations were associated with increased all-cause and HCM-related mortality. Adjusted HRs were 2.52 (95% CI 1.13–5.61, p = 0.024) and 4.86 (95% CI 1.74–13.58, p = 0.003) for all-cause mortality and HCM-related mortality in the lowest SUA group (<250 µmol/L) when compared with the reference group (250–350 µmol/L), respectively. The corresponding HRs in the highest SUA group (≥450 µmol/L) were 2.73 (95% CI 1.42–5.23, p = 0.003) and 4.14 (95% CI 1.70–10.13, p = 0.002), respectively.

Conclusions. Both low and high SUA concentrations were significantly associated with increased risk of all-cause mortality and HCM-related mortality, which supported a U-shaped association between SUA concentrations and mortality in HCM patients.

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Published
2020-02-04
How to Cite
Wang Z., Xu Y., Liao H., Chen X., & He S. (2020). U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients. Upsala Journal of Medical Sciences, 125(1), 44-51. https://doi.org/10.1080/03009734.2020.1719245
Section
Original Articles