Correlation analysis of coagulation dysfunction and liver damage in patients with novel coronavirus pneumonia: a single-center, retrospective, observational study

  • Sai Chen Department of Blood Transfusion, the Third Xiangya Hospital of Central South University, Changsha, China http://orcid.org/0000-0003-4677-0169
  • Hanting Liu Department of Blood Transfusion, the Third Xiangya Hospital of Central South University, Changsha, China
  • Tie Li Department of Clinical Laboratory, the First People’s Hospital of Yueyang, Yueyang, China
  • Rong Huang Department of Blood Transfusion, the Third Xiangya Hospital of Central South University, Changsha, China
  • Rong Gui Department of Blood Transfusion, the Third Xiangya Hospital of Central South University, Changsha, China http://orcid.org/0000-0001-7790-0291
  • Junhua Zhang Department of Blood Transfusion, the Third Xiangya Hospital of Central South University, Changsha, China http://orcid.org/0000-0001-7028-0632
Keywords: Blood coagulation dysfunction, COVID-19, liver damage, pneumonia, SARSCoV- 2

Abstract

Background: The novel coronavirus disease 2019 (COVID-19) is currently breaking out worldwide. COVID-19 patients may have different degrees of coagulopathy, but the mechanism is not yet clear. We aimed to analyse the relationship between coagulation dysfunction and liver damage in patients with COVID-19.

Methods: A retrospective analysis of 74 patients with COVID-19 admitted to the First People’s Hospital of Yueyang from 1 January to 30 March 2020 was carried out. According to the coagulation function, 27 cases entered the coagulopathy group and 47 cases entered the control group. A case control study was conducted to analyse the correlation between the occurrence of coagulation dysfunction and liver damage in COVID-19 patients.

Results: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST), markers of liver damage, were positively correlated with coagulopathy (p = 0.039, OR 2.960, 95% CI 1.055–8.304; and p = 0.028, OR 3.352, 95% CI 1.137–9.187). Alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GT), and total bilirubin (TBIL) were not statistically correlated with coagulopathy. According to the diagnosis and treatment plan, the included cases were classified into mild, moderate, severe, and critical. The results showed that the occurrence of coagulation dysfunction had no statistical correlation with the severity of COVID-19.

Conclusions: Coagulation dysfunction in patients with COVID-19 is closely related to liver damage. A longer course of the disease may cause a vicious circle of coagulopathy and liver damage. Clinicians need to closely monitor coagulation and liver function tests and to give prophylactic or supportive therapy when needed.

Downloads

Download data is not yet available.
Published
2020-09-29
How to Cite
Chen, S., Liu, H., Li, T., Huang, R., Gui, R., & Zhang, J. (2020). Correlation analysis of coagulation dysfunction and liver damage in patients with novel coronavirus pneumonia: a single-center, retrospective, observational study. Upsala Journal of Medical Sciences, 125(4), 293–296. https://doi.org/10.1080/03009734.2020.1822960
Section
Original Articles