Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes

  • Tomoaki Koakutsu
  • Ryosuke Nomura
  • Satoshi Yamanouchi
  • Shigeki Kushimoto
  • Eiji Itoi
  • Yotaro Shinozawa

Abstract

Two cases of necrotizing soft tissue infection of the lower extremity were treated concurrently but independently. Multimodal therapy including hip joint disarticulation and hyperbaric oxygen therapy was administered, resulting in opposite outcomes: survival and death. Analysis of the relationships between patient outcome and time-course changes in serum diacronreactive oxygen metabolites (d-ROMs; an index of oxidative stress), antioxidative potential, and cytokines revealed that serum d-ROMs levels decreased with time, but high serum levels of interleukin-10 (anti-inflammatory cytokine) persisted in the patient who died. These findings may reflect an immunosuppressive status unfavorable to infection prevention. Serum d-ROMs may be a prognostic predictor in necrotizing soft tissue infections.

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Published
2012-11-20
How to Cite
Koakutsu T., Nomura R., Yamanouchi S., Kushimoto S., Itoi E., & Shinozawa Y. (2012). Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes. Upsala Journal of Medical Sciences, 118(1). https://doi.org/10.3109/03009734.2012.733738

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