Myc proteins in brain tumor development and maintenance

  • Fredrik J. Swartling

Abstract

Myc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect children. Many observations have shown how alterations of these pleiotropic Myc transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the role of Myc family members (particularly c-myc and Mycn) in tumors like medulloblastoma and glioma and will further discuss how to target stabilization of these proteins for future brain tumor therapies.

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Published
2012-02-21
How to Cite
SwartlingF. J. (2012). Myc proteins in brain tumor development and maintenance. Upsala Journal of Medical Sciences, 117(2). https://doi.org/10.3109/03009734.2012.658975
Section
Original Articles