Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis

  • Carina Strell
  • Helene Rundqvist
  • Arne Östman

Abstract

Tumor initiation, growth, invasion, and metastasis occur as a consequence of a complex interplay between the host environment and cancer cells. Fibroblasts are now recognized as a key host cell type involved in host–cancer signaling. This review discusses some recent studies that highlight the roles of fibroblasts in tumor initiation, early progression, invasion, and metastasis. Some clinical studies describing the prognostic significance of fibroblast-derived markers and signatures are also discussed.

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Published
2012-02-21
How to Cite
StrellC., RundqvistH., & ÖstmanA. (2012). Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis. Upsala Journal of Medical Sciences, 117(2). https://doi.org/10.3109/03009734.2012.654859
Section
Review Articles