Platelet kinetics after slow versus standard transfusions: A pilot study

  • Abbas Habibi Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Mohsen Esfandbod Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Hossein Ghafari Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Patricia Khashayar Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Atabak Najafi Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Reza Shariat Moharari Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
Keywords: Platelet decline, slow platelet transfusion, standard platelet transfusion

Abstract

Background. Platelet transfusion is required in the acute phase of some thrombocytopenic disorders in order to prevent potentially dangerous hemorrhages.The purpose of this study was to assess the increase in platelet count following a slow platelet transfusion.

Methods. Patients suffering from thrombocytopenia due to various underlying diseases were enrolled in the prospective pilot feasibility trial and were randomly divided into two groups. Standard platelet transfusion was administered in one group, while slow transfusion was used in the other. The platelet count was examined at 1 hour, 24 hours, and 1 week following the transfusions.

Results. Although the platelet count was higher following 1 hour after transfusion via the standard method, the count tended to be higher 1 week after the transfusion in the slow transfusion group. This difference, however, only turned out to be statistically significant amongst females.

Conclusion. A therapy of slow platelet transfusion might be more effective for the prevention of platelet loss. Further studies will be required to strengthen this hypothesis.

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Published
2011-06-17
How to Cite
Habibi, A., Esfandbod, M., Hossein Ghafari, M., Khashayar, P., Najafi, A., & Shariat Moharari, R. (2011). Platelet kinetics after slow versus standard transfusions: A pilot study. Upsala Journal of Medical Sciences, 116(3), 212–215. https://doi.org/10.3109/03009734.2011.569588
Section
Original Articles