Mean platelet volume and its relationship with carotid atherosclerosis in subjects with non-alcoholic fatty liver disease

  • GULDEM KILCILER Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • HALIL GENC Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • SERKAN TAPAN Department of Biochemistry, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • FATIH ORS Department of Radiology, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • MUAMMER KARA Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • NURI KARADURMUS Department of Internal Medicine, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • C. NURI ERCIN Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • YILDIRIM KARSLIOGLU Department of Pathology, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • SELIM KILIC Department of Epidemiology, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • SAIT BAGCI Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • M. KEMAL ERBIL Department of Biochemistry, Gulhane School of Medicine, Etlik, Ankara, Turkey
  • TEOMAN DOGRU Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey
Keywords: Fatty liver disease, mean platelet volume

Abstract

Background. Non-alcoholic fatty liver disease (NAFLD) is linked to an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is an emerging risk factor for atherothrombosis.

Aims. The aim of this study was to investigate the levels of MPV in subjects with NAFLD having no confounding factors for atherosclerosis such as obesity, diabetes mellitus, and hypertension. In addition, the possible relationship between MPV and carotid artery intima media thickness (CIMT), a well known marker of subclinical atherosclerosis, was also studied.

Methods. MPV and CIMT levels were measured in 60 biopsy-proven NAFLD subjects and 54 healthy controls. Age and sex were similar between two groups.

Results. Body mass index and waist circumference levels were higher in the NAFLD group when compared to the controls. There were no differences between the two groups regarding LDL cholesterol levels, whereas HDL cholesterol levels were lower in the NAFLD group. MPV and CIMT levels were not different between the two groups. According to the correlation analyses, CIMT levels were positively correlated to age in patients with NAFLD. However, no significant correlation was found between MPV and CIMT levels.

Conclusions. The results of this study do not show any difference in MPV levels between subjects with NAFLD and controls. These finding suggests that in the absence of other metabolic risk factors, MPV might not be involved in the mechanism(s) of increased cardiovascular risk in NAFLD.

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Published
2010-08-23
How to Cite
KILCILERG., GENCH., TAPANS., ORSF., KARAM., KARADURMUSN., ERCINC. N., KARSLIOGLUY., KILICS., BAGCIS., ERBILM. K., & DOGRUT. (2010). Mean platelet volume and its relationship with carotid atherosclerosis in subjects with non-alcoholic fatty liver disease. Upsala Journal of Medical Sciences, 115(4), 253–259. https://doi.org/10.3109/03009734.2010.500062
Section
Original Articles