Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor

  • LEI WANG Department of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P. R. China
  • YIN TONG Department of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P. R. China
  • ZHIMEI CHEN Institute of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P. R. China
  • WEILAI XU Department of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P. R. China
  • JIE JIN Department of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P. R. China
Keywords: ALCL, ALK , chromosomal translocation, hypophyseal tumor

Abstract

Anaplastic large T-cell lymphoma (ALCL) is frequently associated with the t(2;5)(p23;q35). Here, we report a case of ALCL with an atypical translocation of t(2;5)(p24;q13) and other complex translocations. This complex abnormal karyotype may result in chemotherapy resistance and a poor outcome. Interestingly, a hypophyseal tumor was detected simultaneously by magnetic resonance imaging in this case. We think it is probable that the tumor in the hypophysis might be associated with the ALCL.

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Published
2010-10-27
How to Cite
WANG, L., TONG, Y., CHEN, Z., XU, W., & JIN, J. (2010). Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor. Upsala Journal of Medical Sciences, 115(4), 287–290. https://doi.org/10.3109/03009734.2010.500061