Effect of Losartan Treatment on the Proteinuria in Normotensive Patients Having Proteinuria due to Secondary Amyloidosis

  • Ali Riza Odabas Department of Nephrology Ataturk University, School of Medicine, Erzurum, Turkey
  • Ramazan Cetinkaya Department of Nephrology Ataturk University, School of Medicine, Erzurum, Turkey
  • Yilmaz Selcuk Department of Nephrology Ataturk University, School of Medicine, Erzurum, Turkey
  • Habib Bilen Department of Nephrology Ataturk University, School of Medicine, Erzurum, Turkey

Abstract

Secondary amyloidosis (AA amyloidosis) is a well known cause of nephrotic syndrome and renal failure. Several studies in patients with nephrotic syndrome have suggested a beneficial effect of angiotensin-converting enzyme inhibitors (ACEI). Angiotensin II (ATII) receptor antagonists effect on the long term is not known. In this study, we intended to study the effect of losartan, as an ATII receptor antagonist, on proteinuria and renal functions in patients with normotensive secondary amyloidosis. In total 44 patients with biopsy proven AA amyloidosis associated with nephrotic proteinuria were included. The first group of patients (n=22) was treated with losartan 50 mg/day. The second group of patients (n=22) did not receive any specific antiproteinuric treatment. Urinary protein loss was effectively lowered by losartan from 4.38±1.0 to 2.8±0.61 g/day (p<0.0001), whereas the control group showed a slight fall in proteinuria as 4.21±1.06 to 4.12±1.07 g/day (p = 0.176). Hypoalbuminemia improved significantly from 2.52±0.69 to 2.78±0.46 g/dl (p = 0.004), in the losartan group, whereas serum albumin had fallen in the control group from 2.44±0.57 to 2.27±0.41 (p = 0.041). Serum creatinine increased in the control group from 1.52±0.42 to 2.39±0.51 mg/dl (p<0.0001), and in the losartan group from 1.59±0.50 to 1.84±0.6 mg/dl (p<0.001), after 24 months of treatment. The ATII receptor blocker losartan is effective in protecting against the progression of nephropathy due to AA amyloidosis. Symptomatic treatment of proteinuria with losartan is therefore to be considered, especially with severe proteinuria even in normotensive patients.

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Published
2009-07-12
How to Cite
Odabas A. R., Cetinkaya R., Selcuk Y., & Bilen H. (2009). Effect of Losartan Treatment on the Proteinuria in Normotensive Patients Having Proteinuria due to Secondary Amyloidosis. Upsala Journal of Medical Sciences, 106(3), 183–188. https://doi.org/10.3109/2000-1967-142
Section
Original Articles