Radioprotection of the Kidney with Degradable Microspheres
A pilot study in the dog with repeated irradiation
Abstract
The left kidney of 9 dogs was irradiated daily for three days with 300 kVp X-rays. Radioprotection was attempted in 5 of the kidneys by administration of degradable microspheres in the renal artery, immediately before irradiation. Protected kidneys received 3 × 8 or 3 × 12 Gy in midplane dose, unprotected kidneys 3 × 5.2 or 3 × 8 Gy. A protective effect due to induced hypoxia could be demonstrated in creatinine clearance, which was significantly higher in protected than in unprotected kidneys at 7 – 13 weeks after irradiation.
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Published
1985-09-01
How to Cite
Tuma R., Forsberg J. O., Graffman S., Jung B., & Lynch P. R. (1985). Radioprotection of the Kidney with Degradable Microspheres: A pilot study in the dog with repeated irradiation. Upsala Journal of Medical Sciences, 90(3), 259-263. https://doi.org/10.3109/03009738509178482
Section
Original Articles
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