Serum Concentrations of Estrone, Androstenedione, Testosterone and Sex-hormone-binding Globulin in Postmenopausal Women with Breast Cancer and in Age-matched Controls

Abstract

The concentrations of estrone (E1), androstenedione (A), testosterone (T) and sex-hormone-binding globulin (SHBG) in the serum were determined in 122 postmenopausal women, unselected with respect to age and stage of disease and with a newly diagnosed breast cancer. The results were compared with those in 122 age-matched women without breast cancer, selected from the population register. The patients were found to have a significantly higher mean level than the controls of E1 (132 and 108 pmol/l), A (2.5 and 1.6 nmol/l) and T (1.54 and 1.38 nmol/l) and a lower level of SHBG (40.2 and 47.3 nmol/l) in the serum. A multiple regression analysis revealed in the control group that the serum level of E1 was significantly correlated to A (r=0.48, p < 0.001) and T (r=0.45, p < 0.001). In the patient group E1 was only slightly correlated to T (r=0.25, p < 0.01) and not to A (r=0.10, p > 0.05). A significant negative correlation was found between SHBG and weight in both groups. Otherwise no significant correlations were found between any of the hormone levels and age, stage of disease or weight.

It was concluded that an increased availability of A and T, leading to an increased androgenic stimulation - and therefore decreased SHBG - and an increased E1 level, is the most reasonable explanation for the findings. The lack of correlation between E1 and A in the patient group is however difficult to explain and the results do not seem to fit into a definite hypothesis.