The Effect of O-(β-Hydroxyethyl)-Rutoside (HR) on Macromolecular Leakage, Thrombosis and Haemostasis in Experimental Animals
Abstract
O-(β-hydroxyethyl)-rutoside (HR) (Venoruton®, Zyma AS, Nyon, Switzerland) has been investigated experimentally to evaluate the effect on microvascular permeability and thromboembolism. Permeability to macromolecules is diminished in a hamster cheek-pouch model. Haemostatic plug formation is impaired whereas laser-induced intravascular platelet aggregation is uninfluenced. There is a small but insignificant protection against sodium morrhuate (Eli Lilly and Co., Indianapolis, Indiana) induced femoral vein thrombosis.
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