Effects and Interactions of Oxygen and Prostaglandins on the Tone of the Isolated Human Umbilical Artery

  • TORSTEN TUVEMO
  • KJELL STRANDBERG

Abstract

Prostaglandin E2 (PGE2) and prostaglandin F (PGF) were found to be equipotent contractors of the isolated human umbilical artery (HUA) in the concentration range 0.2–40 μg/ml. Prostaglandin E1 (PGE1) relaxed HUA at 0.1–3.0 μg/ml, whereas at 10–50 μg/ml contraction occurred. PGE2 was significantly more potent at a PO2 of 102 mmHg than at 27, 48 and above 400 mmHg. An increase in PO2 per se (27–>400 mmHg) resulted occasionally in minor increases in the tone of the HUA. Such effects of oxygen had a lag period of 10–15 min. It is suggested that an increased formation of prostaglandins in the umbilical artery at birth is a more likely cause of the closure of the vessel than an increase in PO2.

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Published
1975-11-01
How to Cite
TUVEMO T., & STRANDBERG K. (1975). Effects and Interactions of Oxygen and Prostaglandins on the Tone of the Isolated Human Umbilical Artery. Upsala Journal of Medical Sciences, 80(3), 131-134. https://doi.org/10.3109/03009737509179007
Section
Original Articles

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