Stereospecific Uptake of Narcotic Analgesics by a Subcellular Fraction of the Guinea-pig Ileum:

LARS  TERENIUS

doi:10.3109/03009737309178620

Stereospecific Uptake of Narcotic Analgesics by a Subcellular Fraction of the Guinea-pig Ileum

A Preliminary Communication

LARS TERENIUS From the Department of Pharmacology, University of Uppsala, Uppsala, Sweden

DOI: https://doi.org/10.3109/03009737309178620

Abstract

Longitudinal muscle of guinea-pig ileum was homogenized. Precipitates from centrifugation were incubated with labelled dihydromorphine and competitors. The uptake of label to a high-speed fraction was stereospecific (the analgesics levorphanol and levo-methadone were more active competitors than their inactive dextro-counterparts). Morphine, normorphine, dextromoramide, the antagonists nalorphine and naloxone inhibited uptake. Codeine was inactive.

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Published

1973-11-01

How to Cite

TERENIUS L. (1973). Stereospecific Uptake of Narcotic Analgesics by a Subcellular Fraction of the Guinea-pig Ileum: A Preliminary Communication. Upsala Journal of Medical Sciences, 78(3), 150-152. https://doi.org/10.3109/03009737309178620

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Issue

Vol. 78 No. 3 (1973): Upsala J Med Sci

Section

Original Articles

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