Anti-HCV Antibodies and Hepatocellular Carcinoma

  • Camillo Porta
  • Mauro Moroni
  • Giuseppe Nastasi
  • Giorgio Ricci
  • Ivo Casagranda

Abstract

By means of an accurate immunoenzymatic assay, the prevalence was studied of antibodies to hepatitis C virus (HCV) in three different populations: 74 patients affected with hepatocellular carcinoma (HCC) on preexisting cirrhosis, 82 patients with liver cirrhosis but with no apparent neoplasm, and 70 control subjects, hospitalized for various conditions, of internal medicine or geriatric interest. 70.2% of HCC patients exhibited anti- HBC antibodies, versus 47.5% of cirrhotic subjects with no tumor and 7.1% of controls. Such results suggest the possible role of HCV in the etiopathogenesis of HCC, and its possible synergy with other agents - e.g., hepatitis B virus, alcohol - in causing chronically injured hepatocytes to become neoplastic.

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Published
2010-01-19
How to Cite
Porta, C., Moroni, M., Nastasi, G., Ricci, G., & Casagranda, I. (2010). Anti-HCV Antibodies and Hepatocellular Carcinoma. Upsala Journal of Medical Sciences, 97(3). https://doi.org/10.3109/03009739209179300
Section
Original Articles