Molecular tools to monitor health and disease – and lucky coincidences

Keywords: Padlock probes, proximity ligation, proximity extension, in situ PLA, superRCA, molecular genetics, career, synthetic oligonucleotides, genome project, patent, commercialization


Improved methods for molecular analyses are obviously central for medical research. I will describe herein our work developing tools to reveal molecular states in health and disease. I will recount how I got started in this endeavor, and how our early work characterizing genetic variation led onto high-throughput protein measurements and to techniques for imaging the distribution of proteins and their activity states in tissues. I will also describe a more recent technique to measure even exceedingly rare genetic variants in order to monitor recurrence of disease for tumor patients.


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How to Cite
Landegren U. (2022). Molecular tools to monitor health and disease – and lucky coincidences. Upsala Journal of Medical Sciences, 127(1).