Molecular tools to monitor health and disease – and lucky coincidences

Keywords: Padlock probes, proximity ligation, proximity extension, in situ PLA, superRCA, molecular genetics, career, synthetic oligonucleotides, genome project, patent, commercialization

Abstract

Improved methods for molecular analyses are obviously central for medical research. I will describe herein our work developing tools to reveal molecular states in health and disease. I will recount how I got started in this endeavor, and how our early work characterizing genetic variation led onto high-throughput protein measurements and to techniques for imaging the distribution of proteins and their activity states in tissues. I will also describe a more recent technique to measure even exceedingly rare genetic variants in order to monitor recurrence of disease for tumor patients.

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Published
2022-10-10
How to Cite
Landegren U. (2022). Molecular tools to monitor health and disease – and lucky coincidences. Upsala Journal of Medical Sciences, 127(1). https://doi.org/10.48101/ujms.v127.8987