Maternal, pregnancy and neonatal outcomes in triplet pregnancies in Sweden – a nationwide cohort study
Abstract
Background: Triplet pregnancies carry a high risk of pregnancy-related complications. The primary aim of this study was to describe maternal, pregnancy, and neonatal outcomes in expectantly managed triplet pregnancies in Sweden. The secondary aim was to compare outcomes in expectantly managed triplet pregnancies with triplet pregnancies where fetal reduction had been performed with the only indication to reduce the number of fetuses.
Methods: Nationwide cohort study based on linkage of data from three national Swedish registers. Triplet pregnancies with delivery at gestational age ≥ 22+0 weeks between 2014 and 2019 were included.
Results: In the main cohort of expectantly managed triplet pregnancies (n = 106), 98% (312/318) of infants were liveborn with a mean gestational age at birth of 32+3 weeks and a mean birthweight of 1,726 g. Nine percent (n = 29) suffered from severe neonatal morbidity, and 4% (n = 12) died during the neonatal period. In the reduced cohort (n = 13 pregnancies), all infants were liveborn (n = 22). Mean gestational age at birth (36+0 weeks) and mean birthweight (2,444 g) were higher than in the expectantly managed cohort (P < 0.01 for both comparisons). There were no cases of severe neonatal morbidity (P = 0.24) or mortality (P = 1.00).
Conclusion: Overall neonatal survival from 22+0 weeks of gestation in expectantly managed triplet pregnancies in Sweden was high. Nine out of 10 infants did not suffer from severe neonatal morbidity. Fetal reduction was performed in only a very small number of cases and was associated with higher gestational age at birth and higher birth weight.
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2. Blondel B, Kaminski M. Trends in the occurrence, determinants, and consequences of multiple births. Semin Perinatol. 2002;26(4): 239–49. doi: 10.1053/sper.2002.34775
3. Gleicher N, Kushnir VA, Barad D. Fertility treatments and multiple births in the United States. N Engl J Med. 2014;370(11):1069. doi: 10.1056/NEJMc1400242
4. Karlström PO, Bergh C. Reducing the number of embryos transferred in Sweden-impact on delivery and multiple birth rates. Hum Reprod 2007; 22(8):2202–7. doi: 10.1093/humrep/dem120
5. Socialstyrelsen TNBoHaW, Sweden. Statistics on pregnancies, deliveries and newborn infants. Available from: https://www.socialstyrelsen.se/en/statistics-and-data/statistics/
6. Warner BB, Kiely JL, Donovan EF. Multiple births and outcome. Clin Perinatol 2000;27(2):347–61, ix. doi: 10.1016/s0095-5108(05)70025-7
7. Luke B, Brown MB. Maternal morbidity and infant death in twin vs triplet and quadruplet pregnancies. Am J Obstet Gynecol 2008;198(4):401.e1–10. doi: 10.1016/j.ajog.2007.10.785
8. Wen SW, Demissie K, Yang Q, Walker MC. Maternal morbidity and obstetric complications in triplet pregnancies and quadruplet and higher-order multiple pregnancies. Am J Obstet Gynecol 2004;191(1):254–8. doi: 10.1016/j.ajog.2003.12.003
9. Mazhar SB, Peerzada A, Mahmud G. Maternal and perinatal complications in multiple versus singleton pregnancies: a prospective two years study. J Pak Med Assoc 2002;52(4):143–7.
10. Witteveen T, Van Den Akker T, Zwart JJ, Bloemenkamp KW, Van Roosmalen J. Severe acute maternal morbidity in multiple pregnancies: a nationwide cohort study. Am J Obstet Gynecol 2016;214(5):641.e1–10. doi: 10.1016/j.ajog.2015.11.003
11. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins – Obstetrics, Society for Maternal-Fetal Medicine. Multifetal gestations: twin, triplet, and higher-order multifetal pregnancies: ACOG practice bulletin, number 231. Obstet Gynecol 2021;137(6): e145–62. doi: 10.1097/AOG.0000000000004397
12. Papageorghiou AT, Avgidou K, Bakoulas V, Sebire NJ, Nicolaides KH. Risks of miscarriage and early preterm birth in trichorionic triplet pregnancies with embryo reduction versus expectant management: new data and systematic review. Hum Reprod 2006;21(7):1912–17. doi: 10.1093/humrep/del048
13. Liu Y, Shen Y, Zhang H, Tang Y, Lu G, Lin G, et al. Clinical outcomes of multifetal pregnancy reduction in trichorionic and dichorionic triplet pregnancies: a retrospective observational study. Taiwan J Obstet Gynecol 2019; 58(1): 133–8. doi: 10.1016/j.tjog.2018.11.025
14. van de Mheen L, Everwijn SM, Knapen MF, Oepkes D, Engels M, Manten GT, et al. The effectiveness of multifetal pregnancy reduction in trichorionic triplet gestation. Am J Obstet Gynecol 2014;211(5):536.e1–6. doi: 10.1016/j.ajog.2014.04.023
15. Dudenhausen JW, Misselwitz B, Piedvache A, Maier RF, Weber T, Zeitlin J, et al. Characteristics, management and outcomes of very preterm triplets in 19 European regions. Int J Gynaecol Obstet 2019;147(3):397–403. doi: 10.1002/ijgo.12939
16. Stephansson O, Petersson K, Björk C, Conner P, Wikström AK. The Swedish Pregnancy Register – for quality of care improvement and research. Acta Obstet Gynecol Scand 2018;97(4):466–76. doi: 10.1111/aogs.13266
17. Norman M, Källén K, Wahlström E, Håkansson S. The Swedish Neonatal Quality Register – contents, completeness and validity. Acta Paediatr 2019;108(8):1411–18. doi: 10.1111/apa.14823
18. Hospital KU. Fetal therapy register. 2022. Available from: https://wwwkarolinskase/for-vardgivare/tema-kvinnohalsa/centrum-for-fostermedicin-for-vardgivare/fosterterapiregistret-huddinge/
19. 2008:207: SMoJS. Lag om ändring i folkbokföringslagen [law on changes in the law on civil registration SFS 1991:481]. 2008.
20. Domellöf M, Jonsson B. The Swedish approach to management of extreme prematurity at the borderline of viability: a historical and ethical perspective. Pediatrics 2018;142(Suppl 1):S533–8. doi: 10.1542/peds.2018-0478C
21. Reports from the Swedish Council on Technology Assessment in Health Care (SBU). Int J Technol Assess Health Care 1999;15(2):424–36. doi: 10.1017/S0266462399052605
22. Initiative C. Crown core outcomes in women’s and newborn health. Available from: http://www.crown-initiative.org/core-outcome-sets/ongoing-core-outcome-sets-2/
23. The Swedish Pregnancy Register. Homepage. Available from: https://www.medscinet.com/gr/default.aspx
24. Wyns C, Bergh C, Calhaz-Jorge C, De Geyter C, Kupka MS, Motrenko T, et al. ART in Europe, 2016: results generated from European registries by ESHRE. Hum Reprod Open 2020;2020(3):hoaa032. doi: 10.1093/hropen/hoaa032
25. Razaz N, Avitan T, Ting J, Pressey T, Joseph KS. Perinatal outcomes in multifetal pregnancy following fetal reduction. CMAJ 2017;189(18): E652–8. doi: 10.1503/cmaj.160722
26. Morlando M, Ferrara L, D’Antonio F, Lawin-O’Brien A, Sankaran S, Pasupathy D, et al. Dichorionic triplet pregnancies: risk of miscarriage and severe preterm delivery with fetal reduction versus expectant management. Outcomes of a cohort study and systematic review. BJOG 2015;122(8):1053–60. doi: 10.1111/1471-0528.13348
27. National Institute for Health and Care Excellence: Guidelines. Twin and triplet pregnancy. London: National Institute for Health and Care Excellence (NICE); 2019.
28. Mhatre M, Craigo S. Triplet pregnancy: what do we tell the prospective parents. Prenat Diagn 2021;41(12):1593–601. doi: 10.1002/pd.5852
29. Curado J, D’Antonio F, Papageorghiou AT, Bhide A, Thilaganathan B, Khalil A. Perinatal mortality and morbidity in triplet pregnancy according to chorionicity: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2019;54(5):589–95. doi: 10.1002/uog.20209
30. Shah PS, Kusuda S, Håkansson S, Reichman B, Lui K, Lehtonen L, et al. Neonatal outcomes of very preterm or very low birth weight triplets. Pediatrics 2018;142(6):e20181938. doi: 10.1542/peds.2018-1938
31. Mitsiakos G, Gialamprinou D, Chatziioannidis I, Pouliakis A, Kontovazainitis CG, Chatzigrigoriou F, et al. Are neonatal outcomes of triplet pregnancies different from those of singletons according to gestational age? J Perinat Med 2021;49(9):1145–53. doi: 10.1515/jpm-2020-0558
32. Martin JA, Hamilton BE, Osterman MJK, Driscoll AK. Births: final data for 2019. Natl Vital Stat Rep 2021;70(2):1–51.
33. Shiva M, Mohammadi Yeganeh L, Mirzaagha E, Chehrazi M, Bagheri Lankarani N. Comparison of the outcomes between reduced and nonreduced triplet pregnancies achieved by assisted reproductive technology. Aust N Z J Obstet Gynaecol 2014;54(5):424–7. doi: 10.1111/ajo.12225
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