@article{He_Xu_Dai_2012, title={Dexmedetomidine reduces the incidence of fentanyl-induced cough: A double-blind, randomized, and placebo-controlled study}, volume={117}, url={https://ujms.net/index.php/ujms/article/view/6035}, DOI={10.3109/03009734.2011.629749}, abstractNote={<p>Objectives. The incidence of fentanyl-induced cough (FIC) during induction of general anesthesia varies around 40% and is undesirable. It increases intracranial, intraocular, and intra-abdominal pressures. This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexmedetomidine (DEX) pretreatment on the incidence and severity of FIC.</p> <p>Methods. Altogether 300 patients undergoing elective surgical procedures were randomly allocated into three groups (I, II, III; n = 100) and administered intravenously, over 10 min, 10 mL isotonic saline, DEX 0.5 mg/kg in 10 mL isotonic saline, or DEX 1 mg/kg in 10 mL isotonic saline, respectively. All groups subsequently received a fentanyl (4.0 mg/kg) intravenous push. The incidence and severity of cough were recorded for 1 min after fentanyl administration.</p> <p>Results. The incidence of FIC was 61%, 40%, and 18% in groups I, II, and III, respectively (P &lt; 0.05 for treatment groups II and III versus control group I). There was no significant difference in the severity or onset time of cough, or hemodynamic variables, among the three groups.</p> <p>Conclusions. Intravenous DEX (0.5 mg/kg or 1 mg/kg) immediately before the administration of intravenous fentanyl (4.0 mg/kg) significantly reduced the incidence of FIC.</p&gt;}, number={1}, journal={Upsala Journal of Medical Sciences}, author={He Liang and Xu Jun-Mei and Dai Ru-Ping}, year={2012}, month={Feb.}, pages={18-21} }