@article{MADEJ_GIEREK-CIACIURA_HABERKA_LEKSTON-MADEJ_BASIAK_DOMAŃSKA_OKOPIEŃ_2010, title={Effects of bisoprolol and cilazapril on the central retinal artery blood flow in patients with essential hypertension—preliminary results}, volume={115}, url={https://ujms.net/index.php/ujms/article/view/6128}, DOI={10.3109/03009734.2010.487951}, abstractNote={<p><em>Background.</em>&nbsp;A growing body of evidence suggests that effective blood pressure reduction may inhibit the progression of microvascular damage in patients with essential arterial hypertension. However, the potential influence of anti-hypertensive drugs on ocular circulation has not been studied sufficiently.</p> <p><em>Purpose.</em>&nbsp;The aim of our study was to evaluate the effects of anti-hypertensive therapy on blood flow in the central retinal artery in patients with systemic arterial hypertension.</p> <p><em>Material and methods.</em>&nbsp;Twenty patients with essential arterial hypertension, aged 32–46 years, were examined with Doppler ultrasonography (10 MHz ultrasound probe). Blood flow velocities, pulsatility, and vascular resistance were determined before and 3 hours after systemic application of either bisoprolol 5 mg or cilazapril 2.5 mg.</p> <p><em>Results.</em>&nbsp;Administered bisoprolol significantly decreased maximum (9.8 ± 0.5 cm/s versus 8.5 ± 0.6 cm/s;&nbsp;<em>P</em>&nbsp;&lt; 0.05) and minimum (2.75 ± 0.19 cm/s versus 1.75 ± 0.27 cm/s;&nbsp;<em>P</em>&nbsp;&lt; 0.02) velocity, increased the Pourcellot’s index (0.71 to 0.79;&nbsp;<em>P</em>&nbsp;&lt; 0.05) in central retinal artery. There were no statistically significant changes in central retinal artery blood flow after administration of cilazapril.</p> <p><em>Conclusion.</em>&nbsp;Systemic application of beta-blockers may unfavourably disturb the ocular blood flow.</p&gt;}, number={4}, journal={Upsala Journal of Medical Sciences}, author={MADEJ ANDRZEJ and GIEREK-CIACIURA STANISŁAWA and HABERKA MACIEJ and LEKSTON-MADEJ JOANNA and BASIAK MARCIN and DOMAŃSKA OLGA and OKOPIEŃ BOGUSŁAW}, year={2010}, month={Sep.}, pages={249–252} }