@article{Mutschler_Gustafsson_Basu_Larsson_Eriksson_2009, title={Ropivacaine May Have Advantages Compared to Bupivacaine in Porcine Endotoxemic Shock}, volume={111}, url={https://ujms.net/index.php/ujms/article/view/6432}, DOI={10.3109/2000-1967-035}, abstractNote={<p>Patients that undergo major abdominal surgery often receive epidural postoperative analgesia. Septic complications are frequently seen in this cohort. In a porcine model of endotoxemic shock, resembling human gram-negative septic shock, we evaluated the effects of two widely used local anaesthetics, bupivacaine and ropivacaine given intravenously. In the endotoxin-ropivacaine group mixed venous saturation and platelet count were higher as compared to endotoxemic controls. Mean arterial blood pressure and platelet count were higher in ropivacaine-endotoxin pigs than in bupivacaine-endotoxin ones. Bupivacaine augmented endotoxin-mediated decrease in left ventricular stroke work index. Ropivacaine displays pathophysiological advantages compared to bupivacaine in septic shock, which may be explained by improved tissue perfusion by ropivacaine.</p&gt;}, number={2}, journal={Upsala Journal of Medical Sciences}, author={Mutschler Diana K. and Gustafsson Urban and Basu Samar and Larsson Anders O. and Eriksson Mats B.}, year={2009}, month={Jul.}, pages={189–200} }