Staphylococcus aureus bacteremia and cardiac implantable electronic devices in a county hospital setting: a population-based retrospective cohort study

  • Sara Pichtchoulin Department of Clinical Physiology, Västmanland County Hospital, Västerås, Sweden
  • Ingrid Selmeryd Department of Infectious Diseases, Västmanland County Hospital, Västerås, Sweden
  • Elisabeth Freyhult Department of Microbiology, Västmanland County Hospital, Västerås, Sweden
  • Pär Hedberg Department of Clinical Physiology, Västmanland County Hospital, Västerås, Sweden; and Centre for Clinical Research, Uppsala University, Västmanland County Hospital, Västerås, Sweden https://orcid.org/0000-0001-5731-966X
  • Jonas Selmeryd Department of Clinical Physiology, Västmanland County Hospital, Västerås, Sweden; and Centre for Clinical Research, Uppsala University, Västmanland County Hospital, Västerås, Sweden https://orcid.org/0000-0002-1355-0250
Keywords: Staphylococcus aureus, cardiac implantable electronic device, endocarditis, pacemaker

Abstract

Background: Due to a high incidence of cardiac implantable electronic device-associated infective endocarditis (CIED-IE) in cases of Staphylococcus aureus bacteremia (SAB) and high mortality with conservative management, guidelines advocate device removal in all subjects with SAB. We aimed to investigate the clinical course of SAB in patients with a CIED (SAB+CIED) in a Swedish county hospital setting and relate it to guideline recommendations.

Methods: All CIED carriers with SAB, excluding clinical pocket infections, in the County of Västmanland during 2010–2017 were reviewed retrospectively.

Results: There were 61 cases of SAB+CIED during the study period, and CIED-IE was diagnosed in 13/61 (21%) cases. In-hospital death occurred in 19/61 (31%) cases, 34/61 (56%) cases were discharged with CIED device retained, and 8/61 (13%) cases were discharged after device removal. Subjects dying during hospitalization were elderly and diseased. No events was seen if the CIED was removed. Among four discharged cases with conservatively managed CIED-IE one relapse occured. Among 30 cases discharged with retained CIED and no evidence of IE, 22/30 (73%) cases had an uneventful follow-up, whereas adverse events secondary to overlooked CIED-IE were likely in 1/30 (3%) cases and could not be definitely excluded in additionally 4/30 (13%) cases.

Conclusions: During the study period, management became more active and prognosis improved. The heterogeneity within the population of SAB+CIED suggests that a management strategy based on an individual risk/benefit analysis could be an alternative to mandatory device removal.

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Published
2021-03-05
How to Cite
Pichtchoulin, S., Selmeryd, I., Freyhult, E., Hedberg, P., & Selmeryd, J. (2021). Staphylococcus aureus bacteremia and cardiac implantable electronic devices in a county hospital setting: a population-based retrospective cohort study. Upsala Journal of Medical Sciences, 126(1). https://doi.org/10.48101/ujms.v126.5653
Section
Original Articles