Effects of bisoprolol and cilazapril on the central retinal artery blood flow in patients with essential hypertension—preliminary results

ANDRZEJ  MADEJ; STANISŁAWA  GIEREK-CIACIURA; MACIEJ  HABERKA; JOANNA  LEKSTON-MADEJ; MARCIN  BASIAK; OLGA  DOMAŃSKA; BOGUSŁAW  OKOPIEŃ

doi:10.3109/03009734.2010.487951

ANDRZEJ MADEJ Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
STANISŁAWA GIEREK-CIACIURA Department of Ophthalmology, Medical University of Silesia, Katowice, Poland
MACIEJ HABERKA Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
JOANNA LEKSTON-MADEJ Department of Ophthalmology, Medical University of Silesia, Katowice, Poland
MARCIN BASIAK Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
OLGA DOMAŃSKA Department of Ophthalmology, Medical University of Silesia, Katowice, Poland
BOGUSŁAW OKOPIEŃ Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland

DOI: https://doi.org/10.3109/03009734.2010.487951

Keywords: Bisoprolol, central retinal artery, cilazapril, Doppler ultrasonography

Abstract

Background. A growing body of evidence suggests that effective blood pressure reduction may inhibit the progression of microvascular damage in patients with essential arterial hypertension. However, the potential influence of anti-hypertensive drugs on ocular circulation has not been studied sufficiently.

Purpose. The aim of our study was to evaluate the effects of anti-hypertensive therapy on blood flow in the central retinal artery in patients with systemic arterial hypertension.

Material and methods. Twenty patients with essential arterial hypertension, aged 32–46 years, were examined with Doppler ultrasonography (10 MHz ultrasound probe). Blood flow velocities, pulsatility, and vascular resistance were determined before and 3 hours after systemic application of either bisoprolol 5 mg or cilazapril 2.5 mg.

Results. Administered bisoprolol significantly decreased maximum (9.8 ± 0.5 cm/s versus 8.5 ± 0.6 cm/s; P < 0.05) and minimum (2.75 ± 0.19 cm/s versus 1.75 ± 0.27 cm/s; P < 0.02) velocity, increased the Pourcellot's index (0.71 to 0.79; P < 0.05) in central retinal artery. There were no statistically significant changes in central retinal artery blood flow after administration of cilazapril.

Conclusion. Systemic application of beta-blockers may unfavourably disturb the ocular blood flow.

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