The Role of Subcutaneous Luteinising Hormone Releasing Hormone in the Induction of Ovulation

Abstract

Induction of ovulation using pulsatile luteinising hormone releasing hormone (LHRH) has been performed in 53 anovulatory women who had previously failed to respond to clomiphene. Pelvic ultrasound imaging prior to treatment provided an accurate means of predicting the subsequent response to subcutaneous and intravenous therapy and was of particular value in differentiating patients with ovarian enlargement due to multiple intra-ovarian follicles. Subcutaneous administration was appropriate in the majority of patients. Thirty-eight conceptions have been confirmed.