Investigation of Effect of Various Agents on Periosteal Bone Formation

Abstract

Periosteal bone formation is certainly influenced by several factors. The present investigation shows that immobilization in plaster for a short time has no notable effect on periosteal bone formation after traumatization of the marrow. On the other hand, the traumatization of the animal by daily tube feeding reduces periosteal bone formation markedly, possibly owing to a stress reaction. Tanderil given by feeding tube appears to diminish the reduction of bone formation due to tube feeding alone. Phenytoin given by tube produces no change in the effect of tube feeding alone. Anabolic steroids given as a single injection during the period in question produce a non-significant increase in periosteal bone formation.