Associations between dietary advice on modified fibre and lactose intakes and nutrient intakes in men with prostate cancer undergoing radiotherapy

Lisa Söderström; Marina Forslund; Birgitta  Johansson; Anna Ottenblad; Andreas Rosenblad

doi:10.48101/ujms.v127.8261

Lisa Söderström Region Vastmanland – Uppsala University, Centre for Clinical Research, Vastmanland Hospital Vasteras, Västerås, Sweden; and Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden https://orcid.org/0000-0002-8367-1189
Marina Forslund Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden https://orcid.org/0000-0002-5458-078X
Birgitta Johansson Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden https://orcid.org/0000-0001-6226-6849
Anna Ottenblad Medical Affairs, Nutricia Nordica AB, Solna, Sweden https://orcid.org/0000-0001-7672-2999
Andreas Rosenblad Department of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden; Department of Statistics, Stockholm University, Stockholm, Sweden; and Regional Cancer Centre Stockholm-Gotland, Stockholm, Sweden https://orcid.org/0000-0003-3691-8326

DOI: https://doi.org/10.48101/ujms.v127.8261

Keywords: Fibre, lactose, nutrient intake, prostate cancer, radiotherapy

Abstract

Objectives: A variety of non-evidence-based dietary advice on modified fibre and lactose intakes are provided to patients undergoing pelvic radiotherapy to counteract treatment-related bowel symptoms. More knowledge on the nutritional consequences of such advice is needed. This study aimed to explore how advice on modified fibre and lactose intakes during pelvic radiotherapy was associated with nutrient intakes amongst patients with prostate cancer.

Methods: A total of 77 Swedish men who underwent radiotherapy (50/2 Gy + boost 20–30 Gy) in 2009–2014 due to prostate cancer were given dietary advice at radiotherapy onset (baseline) and at 4 and 8 weeks after radiotherapy onset, to modify their fibre and lactose intakes. At baseline, the participants completed a food frequency questionnaire (FFQ) and a 24-h dietary recall. At 4 and 8 weeks, the participants completed the FFQ and a 4-day estimated food record.

Fibre and lactose intakes were measured by intake scores calculated from the FFQs. Multiple linear regression models were used to analyse associations between intake scores and fibre- and lactose-related nutrients.

Results: In adjusted analyses, there were few significant associations between dietary advice on modified fibre and lactose intakes and observed intakes of fibre- and lactose-related nutrients. A more modified lactose intake was thus associated with a lower intake of calcium (P = 0.041), whilst a more modified fibre intake was associated with a higher value for the change in intake of vitamin C (P = 0.016).

Conclusions: Dietary advice on modified fibre and lactose intake was in most cases not significantly associated with altered nutrient intakes, rather the energy and nutrient intakes were mostly stable during the pelvic radiotherapy. More research is needed on the nutritional consequences of dietary advice on modified fibre and lactose intakes to reach consensus on if they should continue to be provided in the clinic.

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