Ropivacaine May Have Advantages Compared to Bupivacaine in Porcine Endotoxemic Shock

  • Diana K. Mutschler
  • Urban Gustafsson
  • Samar Basu
  • Anders O. Larsson
  • Mats B. Eriksson

Abstract

Patients that undergo major abdominal surgery often receive epidural postoperative analgesia. Septic complications are frequently seen in this cohort. In a porcine model of endotoxemic shock, resembling human gram-negative septic shock, we evaluated the effects of two widely used local anaesthetics, bupivacaine and ropivacaine given intravenously. In the endotoxin-ropivacaine group mixed venous saturation and platelet count were higher as compared to endotoxemic controls. Mean arterial blood pressure and platelet count were higher in ropivacaine-endotoxin pigs than in bupivacaine-endotoxin ones. Bupivacaine augmented endotoxin-mediated decrease in left ventricular stroke work index. Ropivacaine displays pathophysiological advantages compared to bupivacaine in septic shock, which may be explained by improved tissue perfusion by ropivacaine.

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Published
2009-07-12
How to Cite
Mutschler D. K., Gustafsson U., Basu S., Larsson A. O., & Eriksson M. B. (2009). Ropivacaine May Have Advantages Compared to Bupivacaine in Porcine Endotoxemic Shock. Upsala Journal of Medical Sciences, 111(2), 189–200. https://doi.org/10.3109/2000-1967-035
Section
Original Articles