Composition of Surface Layers in Unfixed Autologous Fascia Lata Heart Valve Grafts
A transmission electron microscopical study
Sixty-nine patients underwent aortic valve replacement with frame mounted non-fixated fascia lata grafts. Nine patients still have their fascia lata valve in place after a period of between 9 to 11 years. Fifty-two grafts were available for histo-pathologic examination. The mechanism of valve thickening was studied by transmission electron microscopy (TEM). The major factor contribution to the thickening seems to be a surface accumulation of complex proteins, fibrin and platelets. Within the valvular tissue itself, sub-cellular degenerative products in cell cytoplasm, the interstitium and in the sub-surface layer also contributed. The thickening never exceeded one fifth of the original thickness of the valve.
Authors retain copyright of their work, with first publication rights granted to Upsala Medical Society. Read the full Copyright- and Licensing Statement.