Fluorouracil Effect on Cytochrome c Reductase Activity of Rat Liver Cell Endoplasmic Reticulum Following Partial Hepatectomy

Abstract

FUra (5-fluorouracil) prevents the appearance of 29 and 18S ribosomal RNA in the liver cell cytoplasm of rat, but permits the appearance of smooth-surfaced endoplasmic reticulum, as is clearly seen following partial hepatectomy. The present investigation revealed that the liver microsomal protein of rats treated with the antimetabolite FUra has a high concentration of NADPH oxidating enzyme in sham as well as in partially hepatectomized rats. There was even a tendency towards increased total amount of NADPH oxidating microsomal enzyme per liver in the FUra-treated rats as compared with control animals.