Human Red Cell Content of Cyclic Nucleotides and Cations upon β-adrenergic Blockade

  • GUNNAR RONQUIST
  • GÖRAN FRITHZ
  • MARYANNE HEDSTRÖM
  • PER ERICSSON

Abstract

The content of cyclic nucleotides (cAMP, cGMP) and Mg2+, Zn2+, Na+ and K+ was determined in human erythrocytes and after beta-adrenergic blockade in healthy individuals. The figures for cAMP and cGMP were 4.20 and 3.36 nmoles/l intracellular volume, respectively. Only slight effects on the cyclic nucleotide content as well as on cation content were seen upon beta-blockade in the erythrocytes. It is concluded that the single determination of red cell cAMP is not a sufficient indicator of beta-adrenergic blockade. The determination of cAMP in combination with cGMP, Zn2+ and Na+ might reflect a betaadrenergic blockade.

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Published
1978-06-01
How to Cite
RONQUIST G., FRITHZ G., HEDSTRÖM M., & ERICSSON P. (1978). Human Red Cell Content of Cyclic Nucleotides and Cations upon β-adrenergic Blockade. Upsala Journal of Medical Sciences, 83(2), 85-88. https://doi.org/10.3109/03009737809179117
Section
Original Articles

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